Tissue damage markers in experimental Chagas' disease

Malondialdehydemia (MDA),, measurements of heart and liver tissue damage (TDU), plasma activity of heart alfa - hydroxybutyrate dehydrogenase (LDH1) and liver lactate dehydrogenase (LDH5) were determined in non-infected mice and in mice infected with 10*5 T. cruzi, Y strain, bloodstream trypomastigotes. All the parameters measured were increased (P < 0,01) in infected mice 8 days after intraperitoneal inoculation. The results indicate that plasma MDA levels can serve as a useful indicator of the systemic tissue injury found in chagas' disease

Correlation between tissue damage and malondialdehydemia in mice infected with Trypanosoma cruzi

Evolution of the acute phase of experimetnal Chagas' disease was correlated with tissue damage and plasma levels of malondialdehyde. heart lesions were quantified by the Tissue Damage Unit (TDU) and malondialdehydemia (MDA) by the colorimetric determination of malondialdehyde. the binary correlations were: C(X,Y) =0.965 (P < 0.001); C(y,Z) =0.784 (P < 0.01); and C(X,Z) =0.824 (P < 0.01), where X = days of infection, Y = TDU means and Z = MDA means. These results show a positive correlation between the duration of the acute phase of experimental Cchagas' disease and TDU, and between the durtion and MDA. The methods for measuring tissue damage and MDA are shown to be simple and adequate for monitoring tissue aggression in the protozoosis studied

Malondialdehydemia and parasitemia during acute phase of experimental Chagas' disease in mice

Parasitemia and malondialdehydemia were compared during the acute phase of the infection caused by the CL and Y strains of T. cruzi. Parasitemia was measured by counting blood trypamastigote forms, and malondialdehydemia by a colorimetric method. The duration of the acute phase of Chagas' disease was correlated with malondialdehydemia in both CL and y strains. The correlations between parasitemia and duration of the acute phase, as well as between parasitemia and malondialdehydemia, were significant only in the group infected with the CL strain. These data suggest that malondialdehydemia may be an adequate parameter for evaluating and monitoring the acute phase in experimental Chagas' disease